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bisphenol a health effects references
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Bisphenol A Health Effects Research References

Ashby, J. and H. Tinwell. 1998. Uterotrophic Activity of Bisphenol A in the Immature Rat. Environmental Health Perspectives, vol. 106, pages 719-720.

Ashby, J., H. Tinwell and J. Haseman, 1999. Lack of Effects for Low Dose Levels of Bisphenol A and Diethylstilbestrol on the Prostate Gland of CF1 Mice Exposed In Utero. Regulatory Toxicology and Pharmacology, vol. 30, pages 156-166.

Bitman, J. and Cecil, H.C. 1970. Estrogenic activity of DDT analogs and polychlorinated biphenyls. J. Agr. Food Ahem. 18(6): 1108-1112.

Bond, G.P., McGinnis, P.M., Cheever, K.L., Harris, S.J., Plotnich, H.B., and Niemeier, R.W. 1980. Reproductive effects of bisphenol A. The Toxicologist. A23, No. 69.

Cagen, S.Z., J.M. Waechter, Jr., S.S. Dimond, W.J. Breslin, J.H. Butala, F.W. Jekat, R.L. Joiner, R.N. Shiotsuka, G.E. Veenstra and Harris, L.R.. 1999a. Normal Reproductive Organ Development in CF-1 Mice Following Prenatal Exposure to Bisphenol A. Toxicological Sciences, vol. 50, pages 36-44. http://www.bisphenol-a.orgpdf/Normal-reprod-organ-mice.pdf

Chahoud, I., O. Fialkowski and C. E. Talsness. 2001. The effects of low and high doses in utero exposure to bisphenol A on the reproductive system of male rat offspring. Reproductive Toxicology, vol. 15, page 589.

Chapin, R.E., Sloane, R.A. 1997. Reproductive assessment by continuous breeding: evolving study design and summaries of ninety studies. Environmental Health Perspectives. 105(Suppl 1):199-395. Available on the Internet at:
http://ntp-server.niehs.nih.gov/htdocs/RT-studies/ABOUT_RACB.html

Costa, D.L. and Tepper, J.S. 1988. Approaches to lung funtion assessment in small mammals. In: Toxicology of the Lung. Ed: D.E. Gardiner, J.D. Crapo and E.J. Massaro, Raven Press, New York.

CSTEE (Scientific Committee on Toxicity, Ecotoxicity and the Environment). 2002. Opinion on the results of the Risk Assessment of Bisphenol A Human Health Part. Available on the Internet at
http://europa.eu.int/comm/food/fs/sc/sct/out156_en.pdf .

Ema, M., S. Fujii, M. Furukawa, M. Kiguchi, T. Ikka, and A. Harazono. 2001. Reproductive Toxicology, vol. 15, pages 505-523.

Dodds, E.C. and Lawson, W. 1936. Synthetic estrogenic agents without the phenanthrene nucleus. Nature 137: 996.

EPA (U.S. Environmental Protection Agency). 2002. EPA Statement Regarding Endocrine Disruptor Low-Dose Hypothesis.

EU RAR, 2003. European Union Risk Assessment Report . Available on the Internet at
http://ecb.jrc.it/Risk-Assessment-Documents/DRAFT/R325_0202_env_hh. pdf
.

Fennell, T.R., R.W. Snyder, S.C. Maness, K.W. Gaido, S.C.J. Sumner and F. Welsch. 2000. “Metabolism and Disposition of Bisphenol A in Female Rats" (Abstract 1740), Society of Toxicology, 39th Annual Meeting, Philadelphia, PA, March 19-23, 2000, Toxicological Sciences (Supplement: The Toxicologist), vol. 54, number 1, March 2000, page 371.

Fialkowski, O., H.-J. Merker, C. E. Talsness and I. Chahoud. 2000. "Histopathological findings in the testes of rat male offspring following prenatal exposure to a low and a high dose of bisphenol A," Abs. 55 in Hormones and Endocrine Disrupters in Food and Water: Possible Impact on Human Health, Copenhagen, May 2000.

George, J.D., Price, C.J., Tyl, R.W., Marr, M.C., and Kimmel, C.A. 1985. Unpublished report entitled "Teratologic Evaluation of Bisphenol A (CAS No. 80-05-7) Administered to CD Rats on Gestational Days 6 Through 15," dated February 15, 1985, for the National Toxicology Program from Research Triangle Institute, Research Triangle Park, NC. [NTIS PN85-205110]

George, J.D., Price, C.J., Tyl, R.W., Marr, M.C., and Kimmel, C.A. 1985a. Unpublished report entitled "Teratologic Evaluation of Bisphenol A (CAS No. 80-05-7) Administered to CD-1 Mice on Gestational Days 6 Through 15," dayed February 15, 1985, for the National Toxicology Program from Rsearch Triangle Institute, Research Triangle Park, NC. [NTIS PB85-205102]

Goldenthal, E.I. 1978. Unpublished report entitled "Reproduction and Ninety Day Feeding Study in Rats," dated December 15, 1978, for General Electric Company from International Research and Development Corporation, Mattawan, MI.

Haighton, L. A., Hlywka, J. J., Doull, J., Kroes, B.S., Lynch, B.S., Munro, I.C. 2002. An evaluation of the possible carcinogenicity of bisphenol A to humans. Reg. Tox. Pharma. 35: 238-254.

Hardin, B.D., Bond, G.P., Sikov, M.R., Andrew, F.D., Beliles, R.P., and Niemeier, R.W. 1981. Testing of Selected Workplace Chemicals for Teratogenic Potential. Scand. J. Work Environ. Hlth. 7: 66-75.

Jekat, F. W., K. Twomey, J. H. Butala, J. H. Butala, S. S. Dimond, R. L. Joiner, R. N. Shiotsuka, G. Stropp, G. E. Veenstra and J. M. Waechter. 2000. Evaluation of oestrogenic potential of bisphenol A in the uterotrophic assay by oral and parenteral route at extended dose ranges. (Abstract 1226), Society of Toxicology, 39th Annual Meeting, Philadelphia, PA, March 19-23, 2000, Toxicological Sciences (Supplement: The Toxicologist), vol. 54, number 1, March 2000, page 261.

Krishnan, A.V., Stathis, P., Permuth, S.F., Tokes, L., and Feldman, D. 1993. Bisphenol A: An estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology. 132: 2279-2286.

Matthews, J.B., K. Twomey and T.R. Zacharewski. 2001. In vitro and in vivo interactions of bisphenol A and its metabolite, bisphenol A glucuronide, with estrogen receptors alpha and beta. Chemical Research in Toxicology, vol. 14(2), pages 149-157.

METI (Japanese Ministry of Economy, Trade and Industry). 2002. "Hazard Assessment of Some Chemical Substances Which Have Been Suspected to be Endocrine Disrupters," pages 328-361.

MHLW (Japanese Ministry of Health, Labor and Welfare). 2002 "The Interim Risk Assessment Report by Review Committee Meeting of MHLW Regarding Hazards to Human Health of Endocrine Disrupting Chemicals," Office of Chemicals Safety, Pharmaceutical and Food Safety Bureau, December 26, 2001 (translated from Japanese).

Morrissey, R.E., George, J.D., Price, C.J., Tyl, R.W., Marr, M.C., and Kimmel, C.A. 1987. The Developmental Toxicity of Bisphenol A in Rats and Mice. Fund. Appl. Toxicol. 8: 571-582.

Morrissey, R.E., Lamb, J.C., Morris, R.W., Chapin, R.E., Gulati, D.K., and Heindel, J.J. 1989. Results and Evaluations of 48 Continuous Breeding Reproduction Studies Conducted in Mice. Fund. Appl. Toxicol. 13: 747-777.

Nagel, S.C., F.S. vom Saal, K.A. Thayer, M.G. Dhar, M. Boechler and W.V. Welshons. 1997. "Relative Binding Affinity-Serum Modified Access (RBA-SMA) Assay Predicts the Relative In Vivo Bioactivity of the Xenoestrogens Bisphenol A and Octylphenol," Environmental Health Perspectives, vol. 105, pages 70-76.

Nitschke, K.D., Quast, J.F., Schuetz, D.J., and Wolfe, E.L. 1985. Bisphenol A: 2-week aerosol inhalation study with Fischer 344 rats. Unpublished report of The Dow Chemical Company dated June 6, 1985.

Nitschke, K.D., Lomax, L.G., Schuetz, D.J., Hopkins, P.J., and Weiss, S.K. 1988. Bisphenol A: 13-week aerosol toxicity study with Fischer 344 rats. Unpublished study of The Dow Chemical Company dated March 18, 1988.

NTP. 1982. Carcinogenesis bioassay of bisphenol A (CAS No. 80-05-7) in F344 rats and B6C3F1 mice (feed study). National Toxicology Program, Technical Report Series No. 215. Available on the Internet at
http://ntp-server.niehs.nih.gov/htdocs/LT-studies/TR215.html

NTP. 1984. Bisphenol A: (CAS No. 80-05-7) Reproduction and fertility assessment in CD-1 mice when administered via subcutaneous Silastic® implants. National Toxicology Program (NTP) Report # RACB82081. Available on the Internet at
http://ntp-server.niehs.nih.gov/htdocs/RT-studies/RACB82081.HTML

NTP. 2001. "The National Toxicology Program Endocrine Disruptors Low-Dose Peer Review Final Report, August, 2001," National Toxicology Program, U.S. Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, N.C. The report, including public comments, is available from the NTP Office of Liaison and Scientific Review, NIEHS, NIH, Research Triangle Park, NC. Available on the Internet at
http://ntp.niehs.nih.gov/ntp/htdocs/liason/LowDosePeerFinalRpt.pdf
.

Pottenger, L.H., J.Y. Domoradzki, D.A. Markham, S.C. Hansen, S.Z. Cagen and J.M. Waechter, Jr. 2000. The relative bioavailability and metabolism of bisphenol A in rats is dependent upon the route of administration. Toxicological Sciences. 54:3-18.

Pritchett, J.J., R.K. Kuester and I.G. Sipes. 2002l Metabolism of Bisphenol A in Primary Cultured Hepatocytes from Mice, Rats and Humans. Drug Metabolism and Disposition. vol. 30, no. 11, pages 1180-1185.

Reel, J.R., Tyl, R.W., Lawton, A.D., and Lamb, J.C. 1984. Unpublished report entitled "Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered Via Subcutaneous Silastic Implants," dated January 20, 1984, for the National Toxicology Program, from Research Triangle Institute, Research Triangle Park, NC. [NTIS PB84-155308].

Reel, J.R., George, J.D., Lawton, A.D., Myers, C.B., and Lamb, J.C. 1985. Unpublished report entitled "Bisphenol A: Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed," dated May 31, 1985, for the National Toxicology Program from Research Triangle Institute, Research Triangle Park, NC. [NTIS PB86-103207].

Schönfelder, G., B. Flick, L. Mayr, C. Talsness, M. Paul and I. Chahoud. 2001. Molecular aspects of low and high dose bisphenol A prenatal exposure. Reproductive Toxicology, vol. 15, page 594.

Talsness, C. E., O. Fialkowski, C. Gericke, H.-J. Merker and I. Chahoud. 2000a. The effects of low and high doses of bisphenol A on the reproductive system of femaleand male rat offspring. Congenital Anom., vol. 40, pages S94-S107.

Talsness, C. E., H.-J. Merker and I. Chahoud. 2000b. Histopathological findings in the vagina of rat female offspring following prenatal exposure to a low and a high dose of bisphenol A. Abs. 56 in Hormones and Endocrine Disrupters in Food and Water: Possible Impact on Human Health, Copenhagen, May 2000.

Talsness, C. E., X. Wu, W. Witthoft and I. Chahoud. 2001. The effects of low and high dose in utero exposure to bisphenol A on the reproductive system of female rat offspring. Reproductive Toxicology, vol. 15, page 596.

Tinwell, H., J. Haseman, P. A. Lefevre, N. Wallis and J. Ashby. 2002. Normal Sexual Development of Two Strains of Rat Exposed in Utero to Low Doses of Bisphenol A. Toxicological Sciences, vol. 68, pages 339-348.

Tyl, R. W., C. B. Myers, M. C. Marr, B. F. Thomas, A. R. Keimowitz, D. R. Brine, M. M. Veselica, P. A. Fail, T. Y. Chang, J. C. Seely, R. L. Joiner, J. H. Butala, S. S. Dimond, S. Z. Cagen, R. N. Shiotsuka, G. D. Stropp, and J. M. Waechter. 2002. Three-Generation Reproductive Toxicity Study of Dietary Bisphenol A in CD Sprague-Dawley Rats. Toxicological Sciences, vol. 68, pages 121-146.

Völkel, W., T. Colnot, G. A. Csanády, J. G. Filser, and W. Dekant. 2002. Metabolism and Kinetics of Bisphenol A in Humans at Low Doses Following Oral Administration. Chem. Res. Toxicol., vol. 15, no. 10, pages 1281-1287.

vom Saal, F.S., P.S. Cooke, D.L. Buchanan, P. Palanza, K.A. Thayer, S.C. Nagel, S Parmigiani and W.V. Welshons. 1998. A Physiologically Based Approach to the Study of Bisphenol A and Other Estrogenic Chemicals on the Size of Reproductive Organs, Daily Sperm Production, and Behavior. Toxicology and Industrial Health, vol. 14, pages 239-260.

Wazeter, F.X. 1976. Unpublished report entitled "Reproduction and Ninety Day Oral Toxicity Study in Rats," dated November 30, 1976, for General Electric Company from International Research and Development Corporation, Mattawan, MI.

Wazeter, F.X. and Goldenthal, E.I. 1976. Unpublished report entitled: Ninety day oral toxicity study in dogs. Prepared for General Electric Corporation by International Research and Development Corporation, Mattawan, MI.
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Health Effects Research

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  Developmental Toxicity


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