Bisphenol A Pharmacokinetics and Metabolism
Bisphenol A (BPA) pharmacokinetic studies have shown that if BPA enters the human body it would swiftly be metabolized safely and excreted. Pharmacokinetic studies measure how much of a chemical is absorbed and distributed into the body, metabolized to other compounds, and eliminated or retained. These measurements can provide key information to perform a safety assessment of the chemical.
Bisphenol A is used in the manufacture of polycarbonate plastic and epoxy resins. Recently, a pharmacokinetic study was conducted on bisphenol A in rats which demonstrated that BPA was rapidly metabolized to a hormonally inactive form and excreted. Another study that compared bisphenol A metabolism in rat, mice and human liver cells showed similar metabolism across the species. Taken all together, the studies indicate that rapid metabolism and excretion would also occur following any possible human exposure.
The pharmacokinetic study also showed that concentrations of bisphenol A in the blood were much lower for oral doses than for other routes of administration, such as injection in the abdominal cavity or under the skin. The oral route of exposure is the most relevant route of possible human exposure. Consequently, safety assessments comparing possible levels of human exposure to no-effect or lowest effect levels should be based on laboratory animal studies using the oral route of exposure. Studies based on other routes of exposure are not comparable to possible human exposures and will not produce realistic safety assessments.
Learn more about BPA metabolism.